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Thread Contributor: TheGreatCornholioRetin-A(tretinoin) for anti-aging
#1
The #1 thing I'm going to cover here is the effect of dosing in respect to collagen, and photo sensitivity. 

Many people suggest starting off at 0.05% and building up to 0.1%. There is no proven scientifically backed reason to do this. Every single comparative study on tretinoin's effect on aging suggests that lower doses are every bit as effective in terms of anti-aging benefits(but not acne).

There is no reason for someone who is not suffering from acne to use a dose higher than 0.025%. This is the absolute maximum dose to be used. Further, using it every single day is similarly pointless. Tretinoin is every bit as effective when used every 3 days as it is when used daily. The one and only comparative study between 0.025% and 0.01%(10% of the standard dose) showed no difference between them in terms of collagen and dermis impact.

You will have much more hydrated skin and be far less photosensitive on a lower infrequent dose. Redness, flaking, itching, should all be minimal if not eliminated.

Your treatment plan:
0.025% Tretinion every 3 days

The science to back this up

https://www.ncbi.nlm.nih.gov/pubmed/7544967

Quote:The concept of low strength tretinoin had gained interest when Griffiths and colleagues (1995)  reported observations made in a 48 week, double-blind, vehicle-controlled trial (n = 90) that compared clinical efficacy and tolerability of 0.025% and 0.1% tretinoin cream. The authors observed that both 0.025% and 0.1% tretinoin resulted in statistically significant improvement in all histological and clinical signs of photoaging as compared with vehicle, but there were no clinically or statistically significant differences between the two concentrations of tretinoin. However, the incidences of adverse effects were significantly greater in the 0.1% tretinoin group as compared with the 0.025% tretinoin group. Thus, it was speculated that low strength tretinoin might be a good option for those patients who can not tolerate standard therapy (0.05%). 

https://www.ncbi.nlm.nih.gov/pubmed/11534915 
Quote:Nykady and colleagues (2001) conducted two 24 weeks, double-blind and vehicle-controlled trials to evaluate the efficacy and tolerability of 0.02% tretinoin cream applied once daily in 328 patients with moderate to severely photodamaged skin. Interestingly, both studies showed that there is significantly greater improvement in clinical signs of photoaging like fine wrinkling, coarse wrinkling, sallowness, and mottled hyperpigmentation (only in one study) as compared with vehicle. Moreover, the treatment was safe and well tolerated in most of the patients. Tretinoin cream 0.02% is now recognized by the FDA for the treatment of photoaging.
https://www.ncbi.nlm.nih.gov/pubmed/8785167 

Quote:Bhawan and colleagues (1996) studied the effect of long-term use (4 years) of tretinoin emollient cream in 27 patients treated with either 0.05% or 0.01% of tretinoin for the first 18 months, followed by 15-month treatment with 0.01% tretinoin and finally 19-month daily treatment with either 0.025% or 0.05% tretinoin. Histological studies indicated that the stratum corneum became compact in the first 3 to 6 months whereas it returned to normal (basket weave pattern) in 12–24 months and remained normal until the end of the therapy. Likewise, granular layer thickness and epidermal thickness were increased in the first 3–6 months, returned to normal in 12–24 months and remained normal until cessation of the therapy. In contrast, epidermal mucin continued to increase and melanin continued to decrease throughout tretinoin treatment. The changes in these 2 components clearly correlated with the observed clinical changes.
https://www.ncbi.nlm.nih.gov/pubmed/9270507 

Quote:Olsen and colleagues (1997a) evaluated the histological and clinical changes occurring in 298 patients after once daily application of either 0.05% or 0.01% tretinoin emollient cream for a duration of 1 year. Significant improvement in histological and clinical markers was observed in both the 0.05% and the 0.01% tretinoin group as compared with vehicle
https://www.ncbi.nlm.nih.gov/pubmed/9270508
Quote:The clinical improvement observed during 48 weeks of once-daily treatment was sustained with three-times weekly applications and to a lesser extent with once-weekly dosing

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