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Thread Contributor: TheGreatCornholioLLLT for skin aging
#1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

Skin starts showing its first signs of aging in the late 20s to early 30s and it usually presents with wrinkles, dyspigmentation, telangiectasia, and loss of elasticity. Common histologic and molecular-level features are reduction in the amount of collagen, fragmentation of collagen fibers, elastotic degeneration of elastic fibers, upregulation of matrix metalloproteinases (MMPs), especially MMP-1 and MMP-2, dilated and tortuous dermal vessels, and atrophy and disorientation of the epidermis.23,24 Both chronological and environmental influences are responsible for the aging process of skin; however photodamage seems to be one of the most important causes of these changes.


 Among patients who received LED photorejuvenation alone, 90% reported that they observed a softening of skin texture and a reduction in roughness and fine lines ranging from a significant reduction to sometimes subtle changes.36 Moreover, patients receiving a thermal photorejuvenation laser with or without additional LED photomodulation (n = 152) reported a prominent reduction in post-treatment erythema and an overall impression of increased efficacy with the additional LED treatment.36,45 This reduction in post-treatment erythema could be attributed to anti-inflammatory effects of LLLT.40 Using different pulse sequence parameters, a multicenter clinical trial was conducted, with 90 patients receiving 8 LED treatments over 4 weeks.37,4648 The outcome of this study showed very favorable results, with over 90% of patients improving by at least one Fitzpatrick photoaging category and 65% of patients demonstrating global improvement in facial texture, fine lines, background erythema, and pigmentation. The results peaked at 4 to 6 months following completion of 8 treatments. Markedly increased collagen in the papillary dermis and reduced MMP-1 were common findings

It is widely accepted that the UV range (< 400 nm) exposure is responsible for almost all damaging photo-induced effects on human skin.5759 Some proposed mechanisms for UV induced skin damage are collagen breakdown, formation of free radicals, inhibition of DNA repair, and inhibition of the immune system.5759Existing solutions to prevent UV induced damaging effects are based on minimizing the amount of UV irradiation that reaches the skin, which is achieved by either avoidance of sun exposure or by use of sunscreens. 

It has recently been suggested that infrared (IR) exposure might have protective effects against UV-induced skin damage mainly by triggering protective/repair responses to UV irradiation. In the natural environment, visible and IR solar wavelengths predominate in the morning and UVB and UVA are maximal around noon which suggest that mammalians already possess a natural mechanism which, in reaction to morning IR radiation, prepares the skin for upcoming potentially damaging UV radiation at noon.

In a further study, Frank et al. studied more specifically the role of the p53 cell signaling pathway in the prevention of UVB toxicity.64 The response to IR irradiation was shown to be p53 dependent which further suggests that IR irradiation prepares cells to resist and/or to repair further UVB-induced DNA damage. Finally, the IR induction of defense mechanisms was supported by Applegate et al. who reported that the protective protein, ferritin, normally involved in skin repair (scavenger of Fe2+ otherwise available for oxidative reactions) was induced by IR radiation.

LED based therapy prior to UV exposure provided significant dose-related protection against UVB induced erythema. A significant reduction in UVB induced erythema reaction was observed in at least one occasion in 85% of subjects as well as in the patients suffering from PLE. Furthermore, a sun protection factor SPF-15-like effect and a reduction in post-inflammatory hyperpigmentation were observed. 

The introduction of LED array-based devices has simplified the application to large areas of skin. There is no agreement as yet on several important parameters particularly whether red, NIR, or a combination of both wavelengths is optimal for any particular application. There is a credibility gap that needs to be overcome before LLLT is routinely applied in every dermatologist’s office.

(Yesterday, 02:59 AM)Vitriol Wrote: He broke her heart and she broke his HTPA.

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#2
i am to low iq to read this all 
can you give some tldr version?
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#3
(05-15-2018, 07:01 PM)incellord1 Wrote: i am to low iq to read this all 
can you give some tldr version?
Just put the tip in, and let me handle the rest.

(Yesterday, 02:59 AM)Vitriol Wrote: He broke her heart and she broke his HTPA.

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#4
so you only need to bother about it when you are in your late 20s?
or can this light therapy give you in general a better skin?
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#5
(05-15-2018, 08:07 PM)incellord1 Wrote: so you only need to bother about it when you are in your late 20s?
or can this light therapy give you in general a better skin?
It probably helps younger people, though not as much as older people. They obviously didn't study younger people here.

(Yesterday, 02:59 AM)Vitriol Wrote: He broke her heart and she broke his HTPA.

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